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Transcatheter closure of secundum atrial septal defects with the atrial septal defect occlusion system (ASDOS): initial experience in children.

机译:经房间隔缺损闭塞系统(ASDOS)经导管封闭房间隔缺损:儿童的初步经验。

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摘要

OBJECTIVE--To report initial experiences with transcatheter occlusion of atrial septal defects using a new occlusion device. SUBJECTS--10 children aged 1.1 to 14.9 years. INCLUSION CRITERIA--Patients with a body weight above 10 kg, normal pulmonary resistance and an indication for surgical closure of a secundum atrial septal defect, a residual tissue rim of interatrial septum surrounding the defect of more than 5 mm, and a maximum defect diameter of 20 mm. METHODS--The defects were closed by a transcatheter device (ASDOS) consisting of two umbrellas which are introduced over a guidewire loop. Both umbrellas consist of a central body and five arms formed from preshaped nitinol wire covered with a thin polyurethane patch. The central body of the distal umbrella contains a thread, the proximal umbrella contains a bolt. The two umbrellas are connected by screwing the bolt on the thread using a screwdriver catheter. RESULTS--The implantation was performed under echocardiographic guidance; in six of 10 patients, transoesophageal echocardiography was necessary. The "stretched" diameter of the defect evaluated during balloon sizing ranged from 10 to 20 mm, and the pulmonary to systemic blood flow ratio from 1.5:1 to 2.8:1. Transcatheter closure was successfully performed in 9/10 patients using devices with a diameter of 25 mm to 40 mm. No severe complications occurred. However, in one patient with a pre-existing prolonged PR interval brief periods of second and third degree atrioventricular block occurred after the implantation but normalised within 3 d. During a follow up period of 21 to 29 weeks no device embolisation, thromboembolic complications, fractures of the implanted device, atrial perforations, pericardial effusions, obstructions of systemic or pulmonary veins, atrioventricular valve dysfunction, or other complications occurred. CONCLUSIONS--The new device is a promising transcatheter approach for the occlusion of secundum atrial septal defects in children. However, further evaluation and long term data are needed before this transcatheter technique can be recommended.
机译:目的-报告使用新型阻塞装置经导管阻塞房间隔缺损的初步经验。主题--10名1.1至14.9岁的儿童。纳入标准-体重超过10千克,肺阻力正常且有手术闭锁继发性房间隔缺损,房间隔周围残留的组织边缘超过5毫米,最大缺损直径的患者20毫米方法-用经导管装置(ASDOS)封闭缺陷,该装置由两根伞形物组成,并通过导丝环插入。两把雨伞都由一个中央主体和五个臂组成,该臂由覆盖有薄聚氨酯贴片的预成型镍钛诺线形成。远端伞的中心体带有螺纹,近端伞有螺栓。通过使用螺丝刀导管将螺栓拧在螺纹上来连接两个伞。结果-植入是在超声心动图指导下进行的; 10例患者中有6例需要经食管超声心动图检查。在球囊定型过程中评估的缺损的“拉伸”直径为10至20 mm,肺与全身血流之比为1.5:1至2.8:1。 9/10例患者使用直径25 mm至40 mm的设备成功完成了经导管闭合。无严重并发症发生。然而,在一名患者中,PR间期延长,植入后发生了短暂的二,三度房室传导阻滞,但在3天内恢复正常。在21到29周的随访期内,未发生器械栓塞,血栓栓塞并发症,植入器械的骨折,心房穿孔,心包积液,系统或肺静脉阻塞,房室瓣膜功能障碍或其他并发症。结论-该新装置是一种有前景的经导管方法,用于阻塞儿童的继发性房间隔缺损。然而,在推荐这种经导管技术之前,需要进一步的评估和长期数据。

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